Peran Likopen dalam Menurunkan Risiko Penyakit Kardiovakular : A Literature Review

  • Tulus Ervina Lindayanti
DOI: https://doi.org/10.31605/j-healt.v7i2.4849
Keywords: Antioksidan, likopen, penyakit kardiovaskular (CVD)

Abstract

Tingginya angka kematian akibat penyakit kardiovaskular (CVD) menjadi permasalahan kesehatan global yang serius. Data menunjukkan pada tahun 2019 terdapat 17,8 juta kematian akibat CVD dan diprediksi akan terus meningkat hingga 23 juta kasus pada tahun 2030. Faktor-faktor risiko CVD meliputi pola makan tidak sehat, stres oksidatif, dan inflamasi berkontribusi terhadap peningkatan risiko CVD. Tujuan penelitian ini adalah menganalisis peran likopen dalam menurunkan risiko penyakit CVD. Metode yang digunakan  dalam penelitian ini adalah literature review dengan mengumpulkan artikel ilmiah terkait dari berbagai database. Sebanyak 5 artikel yang relevan dan memenuhi kriteria inklusi digunakan dan dianalisis dalam penelitian ini. Hasil penelitian menunjukkan bahwa likopen memiliki sifat antioksidan kuat, sehingga mampu menekan stres oksidatif, dan meningkatkan aktivitas enzim antioksidan dalam tubuh. Selain itu, likopen juga memiliki efek antiinflamasi dengan kemampuannya dalam menghambat aktivitas sitokin proinflamasi dan menurunkan kolesterol total, trigliserida, LDL, serta meningkatkan kadar HDL. Likopen juga berperan dalam mengontrol tekanan darah yang juga merupakan faktor penting dalam pengelolaan risiko CVD. Berdasarkan mekanisme antioksidan, antiinflamasi, regulasi profil lipid dan tekanan darah, likopen memiliki peran signifikan dalam menurunkan risiko CVD. Mengonsumsi makanan yang kaya akan likopen dapat dijadikan sebagai upaya preventif terhadap pencegahan penyakit kardiovaskular.

References

1. Amini, M., Zayeri, F., & Salehi, M. (2021). Trend analysis of cardiovascular disease mortality, incidence, and mortality-to-incidence ratio: results from global burden of disease study 2017. BMC Public Health, 21(1), 1–12. https://doi.org/10.1186/s12889-021-10429-0
2. Bin-Jumah, M. N., Nadeem, M. S., Gilani, S. J., Mubeen, B., Ullah, I., Alzarea, S. I., Ghoneim, M. M., Alshehri, S., Al-Abbasi, F. A., & Kazmi, I. (2022). Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases. Antioxidants, 11(2), 1–21. https://doi.org/10.3390/antiox11020232
3. Deplanque, X., Muscente-Paque, D., & Chappuis, E. (2016). Proprietary tomato extract improves metabolic response to high-fat meal in healthy normal weight subjects. Food and Nutrition Research, 60, 1–8. https://doi.org/10.3402/fnr.v60.32537
4. Han, G. M., & Liu, P. (2017). Higher serum lycopene is associated with reduced prevalence of hypertension in overweight or obese adults. European Journal of Integrative Medicine, 13(February), 34–40. https://doi.org/10.1016/j.eujim.2017.07.002
5. Karimian, B., Soleimani, A., Mohammadsharifi, G., Heshmat-Ghahdarijani, K., Rejali, L., Shafie, D., Amerizadeh, A., & Sadeghi, M. (2022). Effect of Lycopene Supplementation on Some Cardiovascular Risk Factors and Markers of Endothelial Function in Iranian Patients with Ischemic Heart Failure: A Randomized Clinical Trial. Cardiology Research and Practice, 2022(Cvd). https://doi.org/10.1155/2022/2610145
Kura, B., Parikh, M., Slezak, J., & Pierce, G. N. (2019). The influence of diet on microRNAs that impact cardiovascular disease. Molecules, 24(8), 1–16. https://doi.org/10.3390/molecules24081509
6. Li, D., Yang, S., Xing, Y., Pan, L., Zhao, R., Zhao, Y., Liu, L., & Wu, M. (2021). Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target. Frontiers in Cell and Developmental Biology, 9(July), 1–16. https://doi.org/10.3389/fcell.2021.673839
7. Martinez, V. P., Chiva-Blanch, G., Casas, R., Arranz, S., Martínez-Huélamo, M., Urpi-Sarda, M., Torrado, X., Corella, D., Lamuela-Raventós, R. M., & Estruch, R. (2016). Tomato sauce enriched with olive oil exerts greater effects on cardiovascular disease risk factors than raw tomato and tomato sauce: A randomized trial. Nutrients, 8(3), 1–14. https://doi.org/10.3390/nu8030170
8. Petyaev, I. M., Dovgalevsky, P. Y., Klochkov, V. A., Chalyk, N. E., Pristensky, D. V., Chernyshova, M. P., Udumyan, R., Kocharyan, T., Kyle, N. H., Lozbiakova, M. V., & Bashmakov, Y. K. (2018). Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease. Food Science and Nutrition, 6(6), 1770–1777. https://doi.org/10.1002/fsn3.734
9. Przybylska, S., & Tokarczyk, G. (2022). Lycopene in the Prevention of Cardiovascular Diseases. International Journal of Molecular Sciences, 23(4). https://doi.org/10.3390/ijms23041957
10. Rodrigues, J. ., Pinho, O., & Monteiro, P. R. R. (2018). Can lycopene be considered an effective protection against cardiovascular disease? Food Chemistry, 245(November 2017), 1148–1153. https://doi.org/10.1016/j.foodchem.2017.11.055
11. Senoner, T., & Dichtl, W. (2019). Oxidative stress in cardiovascular diseases: Still a therapeutic target? Nutrients, 11(9). https://doi.org/10.3390/nu11092090
Tierney, A. C., Rumble, C. E., Billings, L. M., & George, E. S. (2020). Effect of Dietary and Supplemental Lycopene on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. Advances in Nutrition, 11(6), 1453–1488. https://doi.org/10.1093/advances/nmaa069
12. Valenzuela, C. A., Baker, E. J., Miles, E. A., & Calder, P. C. (2019). Eighteen‑carbon trans fatty acids and inflammation in the context of atherosclerosis. Progress in Lipid Research, 76(September), 101009. https://doi.org/10.1016/j.plipres.2019.101009
13. Wolak, T., Sharoni, Y., Levy, J., Linnewiel-Hermoni, K., Stepensky, D., & Paran, E. (2019). Effect of tomato nutrient complex on blood pressure: A double blind, randomized dose–response study. Nutrients, 11(5). https://doi.org/10.3390/nu11050950
14. Yanai, H., & Yoshida, H. (2019). Beneficial effects of adiponectin on glucose and lipid metabolism and atherosclerotic progression: Mechanisms and perspectives. International Journal of Molecular Sciences, 20(5), 1–25. https://doi.org/10.3390/ijms20051190
15. Zhong, Q., Piao, Y. Y., Yin, S., & Zhang, K. Y. (2022). Association of serum lycopene concentrations with all-cause and cardiovascular mortality among individuals with chronic kidney disease: A cohort study. Frontiers in Nutrition, 9(December), 1–11. https://doi.org/10.3389/fnut.2022.1048884
Published
2025-08-05
Issue
Vol 7 No 2 (2025): Journal of Health, Education and Literacy (J-Healt)
Section
Articles

Copyright (c) 2025 TULUS ERVINA LINDAYANTI

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