Ekstrak Etanol Daun Jati Belanda (Guazuma ulmifolia Lamk) Memperbaiki Profil Lipid Tikus (Rattus norvegicus) Wistar Jantan Dislipidemia

Ethanol Extract of Jati (Guazuma ulmifolia Lamk) leaves Improve Lipid Profile of Rats (Rattus norvegicus) Wistar Male Dyslipidemia

Authors

  • Melita Hidajat Program Magister Biomedik, Fakultas Kedokteran, Universitas Udayana, Kampus Bukit, Jl. Raya Kampus Unud Jimbaran, Kec. Kuta Sel., Kabupaten Badung, Bali 80361
  • I Gusti Made Aman Departemen Farmakologi, Fakultas Kedokteran, Universitas Udayana, Kampus Bukit, Jl. Raya Kampus Unud Jimbaran, Kec. Kuta Sel., Kabupaten Badung, Bali 80361
  • Hendro Sukoco Prodi Peternakan, Fakultas Peternakan dan Perikanan, Universitas Sulawesi Barat, Jl. Prof. Dr. Baharuddin Lopa, S.H., Baurung, Banggae Timur, Baurung, Banggae Timur, Kabupaten Majene, Sulawesi Barat 91412
  • Ferbian Milas Siswanto Program Studi Bioteknologi, Fakultas Ilmu Kesehatan Sains dan Teknologi, Universitas Dhyana Pura, Jl. Raya Padang Luwih, Tegaljaya, Dalung, Kec. Kuta Utara, Kabupaten Badung, Bali 80361

DOI:

https://doi.org/10.31605/jstp.v1i1.541

Keywords:

Dyslipidemic, Jati Leaves Extract, Lipid Profile, Rats Wistar

Abstract

The purpose of this study was to prove that the administration of Jati (Guazuma ulmifolia Lamk) leaves extract improves the lipid profile of dyslipidemic male Wistar rats. Subjects were 20 rats (Rattus norvegicus), male, Wistar strain, dyslipidemia (total cholesterol ≥ 200 mg dl-1), aged 2 months old, weighing 180-200 grams. The control group (10 rats) were given a placebo of 3 ml aquadest (P0) and the treatment group was given extracts of the Jati (Guazuma ulmifolia Lamk) leaves extract of 25 mg kg-1 BW (P1). Before and after treatment for 14 days, total cholesterol, triglyceride, LDL, and HDL levels were examined. The results showed that in the P0 group there were no changes in total cholesterol, triglyceride, LDL, and HDL levels (p>0.05), whereas the P1 group experienced a decrease in total cholesterol, triglyceride and LDL levels (p<0.05) and an increase in HDL levels (p<0.05). The results of this study indicated that the Jati leaves extract was effective to improve the lipid profile of dyslipidemic rats. It was necessary to compare the effectiveness of Jati leaves extract with synthetic dyslipidemia drugs used in the community such as statin.

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Published

01-01-2020

How to Cite

Hidajat, M., Aman, I. G. M., Sukoco, H., & Siswanto, F. M. (2020). Ekstrak Etanol Daun Jati Belanda (Guazuma ulmifolia Lamk) Memperbaiki Profil Lipid Tikus (Rattus norvegicus) Wistar Jantan Dislipidemia: Ethanol Extract of Jati (Guazuma ulmifolia Lamk) leaves Improve Lipid Profile of Rats (Rattus norvegicus) Wistar Male Dyslipidemia. Jurnal Sains Dan Teknologi Peternakan, 1(1), 25–30. https://doi.org/10.31605/jstp.v1i1.541

Issue

Vol. 1 No. 1 (2019): Jurnal Sains dan Teknologi Peternakan

Section

Articles

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